摘要
目的 :探讨肺泡巨噬细胞 (AM)的功能及调控机制。方法 :采用电泳法观察大鼠AM分泌的溶菌酶活性及雄酮、雌二醇对其分泌的影响。结果 :雄酮、雌二醇对大鼠AM溶菌酶有显著促进作用 (P <0 .0 1) ,吲哚美辛能降低雄酮及雌二醇的这种作用。提示性腺功能的衰退、性激素水平的降低可能是机体免疫功能下降 ,易患某些感染性疾病的机理之一。结论 :性激素有促进AM分泌溶菌酶的作用 ,其作用与前列腺素的合成有关。
Aim and Methods: To further explore the functions of alveolar macrophage and their modulation mechanisms,the activity of lysozyme in rat alveolar macrophage assessed by electrophoresis was determined. The effects of androsterone and estradiol on lysozyme secretion and their mechanisms were also studied.Results: The results showed that androsterone and estradiol increased activity of lysozyme significantly ( P <0.01), indomethacin abolished those effects. This suggests that the insufficiency of sex hormones secretion as the retrogression of gonands is involved in the decrease of immunological functions, and the susceptibility to infectious diseases. Conclusion: Sex hormones increased activity of lysozyme, and those effects related to prostaglandin.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2002年第2期176-178,共3页
Chinese Journal of Applied Physiology
关键词
性激素
肺泡巨噬细胞
溶菌酶
分泌
sex hormones
alveolar macrophage
lysozyme
electrophoresis
