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肽核酸对基因调节作用的研究进展

The Development of Peptide Nucleic Acid in Gene Regulation
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摘要 肽核酸 (PNA)是一类人工合成的核酸类似物 ,PNA与核酸链以Waston Crick碱基配对方式稳定互补结合 ,具有高度的亲合性、稳定性、特异性特征 ,PNA能调节基因的复制、转录 (或逆转录 )和翻译过程 ,有着广泛的分子生物学效应 。 Peptide nucleic acid(PNA) is a kind of artificial DNA mimic. PNA hybridizes with DNA or RNA by means of Watson-Crick's base- pairs complementary with high stability, affinity and selectivity. PNA not only regulates DNA replication , but also adjusts DNA transcription (or reverse transcription) and translation. Many applications have been explored as a new kind of molecular biological tool and a gene-targeting strategy.
作者 宫霞 乐国伟 施用晖
机构地区 江南大学食品学院
出处 《生物工程学报》 CAS CSCD 北大核心 2002年第3期282-285,共4页 Chinese Journal of Biotechnology
关键词 肽核酸 基因调节作用 研究进展 基因表达 peptide nucleic acid (PNA), gene expression, regulation
分类号 Q75 [生物学—分子生物学]
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生物工程学报
2002年 第3期

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