血脂康降脂作用与血清一氧化氮关系的研究

Study of cholesterol-lowing therapy with Xuezhikang and serum nitrous oxide

目的 :探讨血脂康降脂治疗及预防冠心病的机制。方法 :测定 38例高胆固醇血症患者在服药前及服药后第 4、8周与 2 0例正常对照者的血脂及血清一氧化氮 (NO)水平。结果 :①治疗前高胆固醇组与对照组相比 ,血清总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C)明显升高 ,NO明显降低。②血脂康治疗 4周后 ,血清TC、LDL C明显下降 ,NO无改变 ,至第 8周 ,血清NO显著上升。③治疗后LDL C下降值与NO上升值呈负相关 (r=- 0 .6 9,P <0 .0 5 )。结论 :血脂康除有效降脂外 ,还能提高血清NO水平 ;血清NO水平随LDL C降低而上升 。

Objective:To assess effect of Xuezhikang on serum cholesterol and nitrous oxide in patients with hypercholesterolemia. Method:The serum lipid and nitrous oxide were determined in control group (20 normal controls) and hypercholesterolemia group (38 patients with primary hypercholesterolemia were treated with Xuezhikang) at before and 4 weeks, 8weeks after treatment. Result:① After 4-8 week treatment, the levels of serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in hyperchlesterolemia group were decreased compared with before treatment. ② The level of nitrous oxide (NO) in hyperchlesterolemia group was significantly increased via 8 weeks treatment (r= -0.69,P< 0.05). Conclusion:Xuezhikang can increase the serum NO Level and decrease the cholesterol level.