感染、炎症与冠心病关系的临床研究

The effect of Chlamydia pneumoniae infection on coronary heart disease

目的 探讨肺炎衣原体 (CP)感染及可溶性细胞间粘附分子 - 1(s ICAM- 1)与冠心病 (CHD)的关系。方法 采用酶标法 (EIA)测定冠心病组 (6 0例 )和对照组 (6 0例 )血清 CP特异性抗体 Ig G,同时应用 EL ISA法测血清 TNF,s ICAM- 1的浓度。结果 急性心肌梗死组 (2 0例 ) CP Ig G阳性 17例 (85 % ) ,不稳定型心绞痛组 (2 0例 )阳性 16例(80 % ) ,稳定型心绞痛组 (2 0例 )阳性 14例 (70 % ) ,对照组阳性 30例 (5 0 % )。急性心肌梗死组、不稳定型心绞痛组与正常对照组相比 ,差异有显著性 (P<0 .0 5 ) ;冠心病组、急性心肌梗死组、不稳定型心绞痛组与正常对照组相比 ,血清 TNF、s ICAM- 1显著增高 (P<0 .0 1)。结论 患者 CP感染、脂质代谢紊乱、粘附分子表达增加、TNF- α作用可能参与了冠心病发生。

Objective To investigate the relationship between CP infection and sICAM-1 levels and coronary heart disease. Methods Serum IgG to CP was measured in 60 patients with CHD and in 60 healthy controls by enzyme immunoassay. Serum concentrations of TNF and sICAM-1 by ELISA. Results Seropositivity for CP IgG were found in 17 cases(85%) in the 20 patients with acute myocardial infraction; 16(80%)in the 20 patients with unstable angina pectoris(UAP) and 14(70%) in the 20 patients with stable angina pectoris(SAP); 36 cases(67%) in the 60 controls. The rate of seropositivity for IgG in CHD patients is significantly higher than those of controls (P< 0.05). Concentrations of serum TNF and sICAM-1 in the acute myocardial infarction or unstable angina pectoris group are significantly higher than those in the control group (all P<0.01). Conclusion CP infection, TNF-α,sICAM-1 might be implicated in the pathogenesis of coronary heart disease.