52例糖尿病性肝损害临床分析

Chinical Evaluation of DM with Hepatocye Damage.

目的 :了解糖尿病及伴酮症或酮症酸中毒 (DK或DKA)时肝损害的情况 ,探讨糖尿病肝损害的相关因素。方法 :在354例糖尿病患者中 ,把有肝损害的52病例分为有或无DK或DKA两组 ,做ALT、AST、TB值的比较。把伴DK或DKA的57病例分为有或无肝损害两组 ,观察与CO2CP、BUN、GLU、OSM水平关系。结果 :糖尿病肝损害的发生率为14 68 % ,伴DK或DKA发生率为29 82 %。伴DK或DKA组ALT、AST、TB升高显著高于无DK或DKA组 (P<0 05)。伴DK或DKA者有肝损害组CO2CP明显低于 ,BUN、GLU、OSM明显高于无肝损害组 (P<0 01)有显著性差异。结论 :酸中毒和脱水是引起糖尿病肝损害的重要因素 。

Obuective:To assess the effect of diabetes(DM) along with diabetes ketosis or ketoaidosis (DK or DKA)on Hepatocyte damage(HD),and to investigate related factors.Metheds:354 cases with DM have been studied.Amang them,52 cases with HD were divided into two groups in which one group has DK or DKA,anther group doesn't and their ALT,AST and TB levels were measured.57 cases with DK or DKA were divided into two groups,one with HD while the other without,and their CO2CP,BUN,GLU,OSM levels were measured.Results:the occurrence rate of HD in DM patients is 14.68% and the rate for DK or DKA is 29.82%.The level of ALT,AST and TB in HD patients with DK or DKA is higher than that of those without DK or DKA(P<0.05).The level of CO2CP is significantly lower,and BUN,GLU,OSM is signficantly heiger amang DK or DKA patients with HD than that of those without HD(P<0.01).Conclusions:Acidosis and dehydration are two important factors for HD of patients with DM.the degree of HD is highly correlated to the severity of DM.