静脉应用胺碘酮治疗充血性心力衰竭并发的室性心动过速

Use of intravenous amiodarone for ventricular tachycardia in patients with congestive heart failure

目的 观察静脉注射胺碘酮治疗充血性心力衰竭并发的室性心动过速的有效性及安全性。方法 对 5 1例充血性心力衰竭并发持续性室性心动过速的患者首剂给予胺碘酮突击量 3～ 5mg/kg ,15min无效再重复突击量。维持量为 6 0 0mg胺碘酮稀释于 5 0 0ml生理盐水中静脉点滴 2 4h。结果 本组 0 5h内平均负荷量 (2 71 5± 82 8)mg ,第 1个 2 4h胺碘酮静脉用量平均 (916 5± 15 3 4)mg。总有效率 88 2 % ,不良反应发生率 15 9% ,无心功能恶化。结论 静脉注射胺碘酮治疗充血性心力衰竭并发的室性心动过速有效 。

Objective The aim of this study is to investigate the effect and safety of intravenous amiodarone (Cordarone) in patients of congestive heart failure(CHF)with ventricular tachycardia(VT).Methods Fifty one patients of CHF with sustained VT received the first bolus of amiodarone(3～5 mg/kg),if sinus rhythum was not restored within 15 mins,the same dosage was repeated.Then,followed by 600 mg amiodarone added into 500 ml normal saline for intravenous drip for 24 hours.Results In VT group,the average loading dose was (271.5±82.8) mg in 30 mins.In the first 24 hours,the total dose of amiodarone was 750～1 050 mg,and the average dose was(916.5±153.4) mg.The total effective rate was 88.2%. The side effective rate was 15.9%,and there was no heart function deterioration occured.Conclusion Amiodarone is safe and effective on the treatment of VT in patients with CHF.