肠易激综合征患者肛门直肠动力学的研究

Dynamic study of the anorectum in patients with irritable bowel syndrome

目的 :探讨肠易激综合征 (IBS)患者肛门直肠动力学的特征。方法 :采用PCPolygrafHR高分辨多道胃肠功能测定仪检测 32例 (IBS)患者的肛门直肠压力、直肠容量感知、疼痛阈值、耐受阈值等指标 ,并与12例健康人做对照。结果 :IBS的直肠静息压、肛管括约肌静息压、最大缩窄压及肛管长度与对照组相比无统计学意义 (P >0 .0 5 ) ,而初始感觉阈值、疼痛阈值、排便阈值腹泻组低于正常对照组 (P <0 .0 5 ) ,便秘组高于正常对照组 (P <0 .0 5 )。排便时IBS便秘组患者的肛管松弛压高于正常对照组 (P <0 .0 5 )。结论 :IBS患者排便功能和直肠感觉功能存在异常。

Objective:To study the features of anorectal dynamics in patients with irritable bowel syndrome(IBS). Methods: Multichannel and single balloon anorectal function detector of PC Polygraf HR was applied in 32 patients with IBS as well as in 12 normal subjects to measure such parameters as anorectal pressure, rectal sensation volume thresholds, rectal defecation volume thresholds,and rectal maximum tolerable volume thresholds. Results:Rectal resting pressure, anal resting pressure, anorectal sphincteric squeezing pressure and the length of high pressure zone were not different between the patients with IBS and normal subjects(P>0.05). Rectal sensation volume thresholds, rectal defecation volume thresholds, rectal maximum tolerable volume thresholds were higher in constipation group of IBS than those in normal subjects(P<0.05). but were lower in diarrhea group of IBS than those in normal subjects(P<0.05). Relaxation pressure of sphincter during defecation was higher in constipation group of IBS than that in normal subjects (P<0.05). Conclusions:Rectal sensation function to irritation and defecation function in patients with IBS was abnormal .