布洛芬分散片的研制

Study on the preparation of dispersible ibuprofen tablets

目的 :研制布洛芬分散片。方法 :以崩解时间为指标比较了不同崩解剂的作用 ,以正交试验设计确立最佳处方 ,并与普通片进行了体外溶出度的比较。结果 :崩解剂以交联聚乙烯吡咯烷酮效果最优 ,最佳处方崩解时间为 89.4s ,溶出速度远大于普通片。结论 :所研制的布洛芬分散片溶出迅速。

Objective: To experiment on the preparation of dispersible ibuprofen tablets. Methods: With the dispersible time as the focus of attention, different disintegrants were compared and orthogonal design was adopted to determine the optimal formulation,and then dissolution rate of dispersible ibuprofen tablets was compared with that of the conventional tablets in the market. Results:Of the four tested disintegrants crospovidone had the best dispersing effect and the dispersible tablets of optimal formulation exhibited a disintegrating time of 89.4s with a much quicker dissolution speed than that of the conventional tablets on sale. Conclusion: The experimented dispersible ibuprofen tablets have a higher dissolution speed than those in the market.