输血相关病毒与丙型肝炎病毒感染者血清ALT变化的关系

The serum level of ALT in patients infected with TTV and HCV

目的 :探讨输血相关病毒 (TTV)在肝脏疾病中的作用。方法 :TTV检测采用 ELISA法。HCV-RNA检测采用 RT-PCR-微板核酸杂交 -ELASA法。结果 :ALT异常率在 HCV单独感染者明显高于 TTV单独感染者 (P<0 .0 1 ) ,而 TTV单独感染者与 TTV、HCV均阴性者间则无明显差异 (P>0 .0 5 )。HCV单独感染者与 TTV、HCV混合感染者平均 ALT水平均明显高于 TTV单独感染及 HCV、TTV均阴性者 (P<0 .0 1 )。HCV单独感染者与 TTV、HCV混合感染者平均 ALT水平差异无显著性 (P>0 .0 5 )。结论 :TTV可能不具有单独致病作用。

Objectove: To study the roles of TTV in the occurance of liver diseases by examing serum levels of ALT in patients infected with TTV and HCV. Methods: ELISA and RT PCR microplate nucleic acid hybridization ELISA were applied to confirm the infections with TTV and HCV, respectively. Results: Rates of ALT abnormality in patients infected with HCV was higher than that in patients infected with TTV( P <0 01),and no difference was observed between TTV infection group and combining TTV and HCV infection group( P >0 05).Levels of ALT in both HCV infection group and combining TTV and HCV infection group were higher than those in alone TTV infection group and combining TTV and HCV infection group( P <0 01), but there was no difference between alone HCV infection group and both TTV and HCV infection group ( P >0 05). Conclusion: TTV may not have the ability to cause liver diseases when it is infected alone.