乙醇处理工艺对大黄致泻活性的影响

Influence of Ethyl Alcohol on Purgative Action of Rhubarb

大黄水提液蒽醌含量低而泻下作用强;醇提液蒽醌含量高而无泻下作用;醇提液去鞣质后仍无致泻作用;有致泻作用的水提液与醇提液混合,致泻作用消失。这一实验结果与中医学“生用大黄泻下,酒制大黄活血祛瘀”的传统经验相吻合,但从蒽醌和鞣质含量的变化着眼,并不能对此给予合理的解释。实验结果提示,乙醇处理直接影响大黄的致泻活性,可使致泻活性消失。研究含有大黄的中药新药提取工艺应对此予以重视。

Experimental studies showed that the water extract of rhubarb had low content of anthraquinone and a strong purgative while the alcohol extract a high content of anthraquinone and was free of purgative action,even tannin was eliminated.The purgative action of the water extract was also last when mixed with alcohol extract. The experimental results coincide with the traditional experience in Chinese medicinal theory:'the fresh Rhubarb has a purgative action while rhubarb prepared with wine can promote blood circulation and remove blood stasis.'However, from the angle of anthraquinone and tannin, the explanation is unreasonable. It is indicated that the purgative action of rhubarb is greatly influenced, even disappears when prepared with alcohol. So, attention should be paid in the preparation process of Chinese patent drugs containing rhubarb.