塞曲司特的合成

Synthesis of seratrodrast

目的 :合成塞曲司特。方法 :以庚二酸单乙酯为原料 ,经酰氯化、傅克酰化、还原、水解、缩合及氧化反应合成塞曲司特。结果 :塞曲司特的总产率为 5 0 .7%。结论 :本方法条件温和 ,操作简单 ,适合于工业化。

Objective:To synthesize seratrodrast.Methods and results:Through acylation,Friedel Crafts reaction,reduction,hydrolysis,condensation and oxidation,the title compound was prepared with a total yield of 50.7%.Conclusion:This synthetic procedure is mild,convenient,simple and suitable to be industralized.