血清铁蛋白水平在成人斯蒂尔病中的诊断价值

Diagnostic Value of Serum Ferritin in Adult Onset Still's Disease

目的 :确定血清铁蛋白 (SF)水平在成人斯蒂尔病 (SD)中的诊断价值。方法 :应用化学发光法测定 12 2例住院患者 (成人SD组 2 7例 ,对照组 95例 )的SF水平 ,并对两组SF平均值和SF升高的频率分别进行t检验和 χ2检验。结果 :成人SD组SF平均值为 (786 6± 5 4 75 ) μg/L ,较对照组 (5 2 7± 36 5 ) μg/L明显升高 (P <0 .0 1)。成人SD组SF值均高于正常值上限 ,其中 7例 (2 5 .9% )低于 5倍正常值 ,2 0例 (74 .1% )高于 5倍正常值。有 7例 (2 5 9% )SF值超过 15 0 0 0 μg/L。而对照组中 2 3例 (2 4 .2 % )SF值正常 ,5 4例 (5 6 .8% )低于 5倍正常值 ,18例 (19.0 % )高于 5倍正常值。对照组中几乎未见SF值大于 15 0 0 μg/L者。结论 :SF水平升高对活动期成人SD具有可靠的实验室诊断价值 ,特别是当SF值大于 15 0 0 μg/L时 ,有助于排除其他炎症性疾病。

Objective: Our aim was to determine diagnostic value of serum ferritin (SF) level in adult onset Still's disease (SD) Methods: We divided 122 patients into adult onset SD group and control group. The levels of SF were measured by using chemilumiescence immunoasay. Results: The mean SF level in the SD group (7866±5475 μg/L) was significantly higher than that in the control group (527±365 μg/L, P< 0.01). In SD group, the SF level of 20 (74.1%) cases was 5 times higher than normal level. While in the control group, the SF level of 18(19 0%) cases was 5 times higher than normal level. Conclusion: The high level of SF has reliable diagnostic value for the acute adult onset SD, especially valuable when SF levels are higher than 1 500 μg/L. It is also useful to exclude other inflammatory diseases.