摘要
目的 :评价复方曲尼司特胶囊 (舒尔泰 )对轻、中度支气管哮喘的平喘效果和不良反应。方法 :采用多中心、随机平行对照、双盲试验方法 ,2 0 9例轻、中度支气管哮喘患者被分成试验组 10 3例和对照组 10 6例 ,分别服用复方曲尼司特胶囊 1粒和硫酸沙丁胺醇片剂 1片 ,q8h ,疗程 2 8d。结果 :试验组和对照组总有效率分别为 84 .5 %(P <0 .0 5 )和 71.7% ;肺功能FEV1有效率分别为 6 8.0 % (P <0 .0 1)和 4 4 .2 % ;不良反应发生率分别为 11.7%(P >0 .0 5 )和 12 .3%。结论 :复方曲尼司特胶囊是一种安全有效的平喘药。
Objective:To evaluate the efficacy and safety of compound tranilast capsules in treatment of mild and moderate bronchial asthma.Methods:The multiple center,randomized paralleled controlled,double blind design was adopted in this study.209 patients were divided into test group( n =103) and control group( n =106) to receive orally one capsule of compound tranilast and one tablet of sulbutamol sulphate once every eight hours for 28d respectively.Results:The total effective rate of test group and control group was 84.5%( P <0.05) and 71.7%;the effective rate of lung function FEV 1 was 68.0%( P <0.05) and 44.2%;the occurrence rate of adverse drugs reaction was 11.7%( P > 0.05) and 12.3%.Conclusion:Compound tranilast capsules is a safe and effective antiasthma drug.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2002年第3期234-236,共3页
Chinese Journal of New Drugs
关键词
复方曲尼司特
硫酸沙丁胺醇
支气管哮喘
compound tranilast capsules
sulbutamol sulphate
bronchial asthma
