MMP-2在胆囊癌中的表达及其意义

Expression and significance of matrix metalloproeinase-2(MMP-2) in gallbladder carcinoma

目的 :探讨基质金属蛋白酶 2 (MMP 2 )在胆囊癌中表达的意义。方法 :采用免疫组织化学法观察MMP 2在 4 1例胆囊癌组织及 10例正常胆囊组织中的表达。结果 :正常胆囊组织未见MMP 2表达 ,4 1例胆囊癌组织中MMP 2阳性表达 36例 (占 87.8% ) ,MMP 2表达的强度与肿瘤TNM分期 (P <0 .0 5 )、淋巴结转移 (P<0 .0 5 )相关 ,而与患者年龄、性别、组织学类型及分化程度无相关性 (P >0 .0 5 )。结论 :MMP 2在胆囊癌的发展过程中起着重要作用 ,MMP 2可作为评价胆囊癌恶性潜能的生物学标记物。

Objective:To evaluate the expression of MMP 2 and its significance in gallbladder carcinoma.Methods:We examined the expression of MMP 2 by using immunohistochemsitry technique.Results:The expression of MMP 2 was not detected in nomal gallbladder tissue. The positive signal rate in gallbladder carcinoma was 87.8%. MMP 2 expression was detected more predominantly in tumor cells than in peritumor stromal cells. The intensity of MMP 2 expression correlated with tumor stage(P<0.05) and lymph node metastasis(P<0.05). However,the expression intensity did not correlate with age,sex and histological type differentiation.Conclusion:Expressin of MMP 2 might play an important role in the development of gallbladder carcinoma,and MMP 2 become a biological marker for evaluating the malignant potential of gallbladder carcinoma.