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抗孕唑对妊娠大鼠子宫收缩力的影响

Effects of DL111-IT on uterine contractivity in pregnant rats
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摘要 目的 :观察抗孕唑对妊娠大鼠子宫收缩力的影响。方法 :以妊娠大鼠的离体子宫为材料 ,加入不同浓度的药物 ,以宫缩张力达最大高度为观察指标。结果 :随着抗孕唑浓度从 1× 10 -9mol·L-1增加到 1× 10 -8,1×10 -7mol·L-1,宫缩作用逐渐增强。 5× 10 -3 和 5× 10 -2 IU·mL-1的催产素对肌注抗孕唑的实验组孕鼠的离体子宫收缩高度分别为 (5 2 .7± 6 .3)和 (10 2 .3± 8.3)mm ,而对肌注茶油的对照组的离体孕鼠子宫的收缩高度分别为(2 6 .5± 3.8)和 (6 5 .5± 7.5 )mm ,2 .6× 10 -7和 2 .6× 10 -6mol·L-1的米索前列醇对实验组的宫缩高度分别为(32 .6± 3.5 )和 (2 5 .5± 4 .0 )mm ,而对照组宫缩高度分别为 (2 3.5± 4 .5 )和 (9.7± 2 .1)mm。结论 :抗孕唑对妊娠大鼠不仅有较弱的直接宫缩作用 ,还能提高子宫对催产素和米索前列醇的敏感性。 Objectives:To observe the effects of DL111 IT on uterine contractivity of pregnant rats in vitro .Methods:The drugs were dropped into early pregnant rat's uterus,and the biggest contractivity was observed as an indication.Results:The contractive intensity was increased with the level elevation of DL111 IT from 1×10 -9 to 1×10 -8 ,1×10 -7 mol·L -1 .After rats were administered intramuscularly by DL111 IT 3mg·kg -1 ·d -1 ,the contractivity of early pregnant rats uterus treated with oxytocin 5×10 -3 and 5×10 -2 IU·mL -1 were (52.7±6.3) and (102.3±8.3) mm respectively,while that of the tea seed oil control group were(26.5±3.8)and (65.5±7.5)mm respectively;and the contractivity of early pregnant rats uterus treated with misoprostol 2.6×10 -7 and 2.6×10 -6 mol·L -1 were (32.6±3.5) and (25.5±4.0)mm respectively,while that of control group were(23.5± 4.5) and (9.7±2.1)mm respectively. Conclusion:DL111 IT can increase weakily the uterine contractivity in pregnant rats,and also enhance the sensitivity of uterus contraction in early pregnant rats to oxytocin and misoprostol.
作者 陈方亮 杨波
出处 《中国新药杂志》 CAS CSCD 北大核心 2002年第3期209-212,共4页 Chinese Journal of New Drugs
关键词 抗孕唑 子宫收缩力 宫缩敏感性 DL111 IT uterine contractivity sensitivity of uterus contraction
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