四安胶囊合用依那普利对高血压病患者降压谷峰比及24小时节律的影响

Effect of Si’an Capsule Combined Enalapril on Hypertensive Trough/Peak Ratio and Circadian Rhythm of Blood Pressure in Patients with Essential Hypertension

目的 :观察四安胶囊与依那普利合用对高血压病患者降压谷峰比及 2 4h节律的影响。方法 :将6 0例高血压病患者 (Ⅱ、Ⅲ期 )随机分成治疗组 (四安胶囊加依那普利组 ,30例 )和对照组 (依那普利组 ,30例 )。治疗前及治疗 4周后分别行 2 4h动态血压监测 ,计算各组降压谷峰比 (T/P) ,观察 2 4h血压节律的变化。结果 :(1)治疗组和对照组降压T/P分别为 :收缩压 (6 2 4± 7 0 ) %、(5 3 3± 6 7) % ,舒张压 (6 6 3± 8 1) %、(6 0 1±7 2 ) % ,治疗组T/P显著高于对照组 (P <0 0 5 )。 (2 )治疗前对照组血压昼夜节律消失者有 16例 ,治疗后 8例(5 0 % )恢复正常 ;治疗组有 15例血压昼夜节律消失 ,治疗后 11例 (73 3% )恢复正常 ,两组恢复率比较差异无显著性 (P >0 0 5 )。结论 :四安胶囊与依那普利合用可平稳降低血压 ,恢复血压昼夜节律。

Objective: To investigate the effect of Si′an Capsule combined Enalapril on hypertensive trough/peak ratio (T/P) and circadian rhythm of blood pressure in patients with essential hypertension (EH). Methods: Sixty patients with EH of stage Ⅱ, Ⅲ were randomly divided into two groups, the 30 patients in the treated group were treated with Si′an capsule combined Enalapril, and the 30 patients in the control group were treated with Enalapril alone. All patients were given 24 hour ambulatory blood pressure monitoring before and after 4 weeks treatment. T/P of systolic and diastolic blood pressure (SBP & DBP) of each group were calculated. Circadian rhythm of blood pressure was observed at the same time. Results: T/P of SBP and DBP in the treated group was 62.4±7.0% and 66.3±8.1% respectively, which was obviously higher than that in the control group, 53.3±6.7% and 60.1±7.2%, respectively (P<0 05). The blood pressure circadian rhythm recovering rate in the treated group was 73.3% and in the control group 50%, the difference was insignificant. Conclusion: The combination therapy of Si′an capsule and Enalapril could lower the blood pressure smoothly and restore the circadian rhythm of blood pressure in EH patients.