类风湿性关节炎患者外周血T细胞亚群异常及调节的研究

Study on Abnormality and Regulation of T-Lymphocyte Subsets in Peripheral Blood of Rheumatoid Arthritis Patients

目的 :观察类风湿性关节炎 (RA)患者外周血T细胞亚群的变化及扶正祛痹汤治疗对T细胞亚群的影响。方法 :将 30例RA患者随机分成两组 ,分别给西药联合治疗及中西药治疗 1个月 ,检测治疗前后外周血CD3+、CD4 +、CD8+百分比和血清Ig值。 结果 :RA患者外周血T细胞CD4 +、CD8+、CD4 +/CD8+比值、血清IgG、IgA水平显著升高 (P <0 0 5 )。中西药治疗后CD4 +/CD8+、IgG、IgA显著降低 (P <0 0 5 )。结论 :RA患者存在细胞免疫异常。中西药合用可治疗调节T细胞亚群比例平衡。

Objective: To investigate the change of T lymphocyte subsets in peripheral blood of rheumatoid arthritis (RA) patients and analyze the effects of Fuzheng Qubi Decoction (FZQBD) on T cell subsets. Methods: Thirty RA patients were randomly divided into two groups, and treated with FZQBD or western medicine combination therapy respectively for one month, the percentage of peripheral CD 3 +, CD 4 +, CD 8 + as well as the serum IgG and IgA levels were determined. Results: The percentage of peripheral CD 4 +, CD 4 +/CD 8 + ratio, IgG and IgA levels increased significantly (P<0 001) in RA patients before treatment. After 1 month of FZQBD treatment, the CD 4 +/CD 8 + ratio decreased obviously (P<0 05). Conclusion: Abnormal cellular immunity exists in RA patients, FZQBD could adjust the abnormal T lymphocyte subsets to normalize it.