江苏汉族人乙醛脱氢酶2基因型分布及其与饮酒习惯的关系

ALDEHYDE DEHYDROGENASE-2 GENOTYPES AND DRINKING BEHAVIOR OF CHINESE IN JIANGSU PROVINCE

目的 :研究乙醛脱氢酶 2 (ALDH2 )基因多态性在江苏汉族人中的分布频率及其与饮酒习惯的关系。方法 :在江苏泰兴市选择 2 73例正常人进行流行病学调查研究 ,并应用聚合酶链反应 限制性片段长度的多态性 (PCR RFLP)方法检测研究对象的ALDH2基因型。结果 :ALDH2变异型等位基因在中国人中的分布频率为 47.2 5 %。ALDH2变异型等位基因携带者与ALDH2正常等位基因携带者之间饮酒频度和每次饮酒量间差异均无显著性。结论 :中国人ALDH2酶的活性普遍缺乏。人们的饮酒习惯与ALDH2基因型分布无明显的相关关系。

Purpose: To analyze the genotype frequency of aldehyde dehydrogenase-2 (ALDH2), and evaluate the relationship between ALDH2 polymorphism and drinking behavior in Chinese. Methods: Epidemiological data were collected from 273 healthy persons in Taixing city of Jiangsu province in China, and ALDH2 genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequency of ALDH2 mutant allele was 47.25 % in Chinese. No difference was found between ALDH-2+1 and ALDH-2+{1*2}/ALDH-2+2 in drinking frequency and alcohol consumption per occasion. Conclusion: The ALDH-2+2 allele was relatively common in Chinese. Drinking behavior was not influenced by the individual genotypes of ALDH2.