固体三元稳态ClO_2急性经口、遗传及蓄积毒性研究

Researches on the acute oral,heredity and cumulative toxicity of trinary solid stable chlorine dioxide disinfectant

固体三元稳态二氧化氯是为了解决二元产品活化率低、活化酸度高、活化损失大的缺点而研制出的新型固体ClO2 产品。通过对其急性经口毒性、遗传毒性及蓄积毒性的试验研究 ,发现雌雄小鼠的急性经口LD50 值均大于 2 1.5 g/kg ,该产品属于实际无毒级 ;剂量达 5 .0 0g/kg ,未检出对雌雄小鼠骨髓嗜多染红细胞的诱变活性 ;给药 2 0d后 ,动物死亡仍未足半数 ,K >5 ,该产品为弱蓄积性。

Trinary solid stable chlorine dioxide is a new type of disinfectant. It is better than the binary products,overcoming the disadvantages such as having low activation rate,high activation acidity and great activation loss. Through experiments on its acute oral, heredity and cumulative toxicity of ClO 2,it is noticed that the acute oral LD 50 of mice are more than 21.5 g/kg weight. So,this disinfectant is actually nontoxic. When the dosage is up to 5 g/kg weight no evocating activation of both male and female mice’s marrow polychromatic erythrocyte can be founded. After 20 day’s application of this disinfectant,the number of dead animal is still less than 50%,the cumulative coefficient K >5,so it is weak in cumulative property.