摘要
目的 :探讨骨髓增生异常综合征 (Myelodysplasticsyndrome ,MDS)各亚型疗效、转归和长期生存的因素。方法 :分析 5 0例MDS各亚型病程进展、演变过程、生存时间、死亡原因。结果 :RA、RAS预后较好 ,病情稳定 ,部分病人可获长期缓解 ,能从事力所能及的工作。RAEB -T预后最差 ,转白率高 ,RAEB介于二者之间 ,转白率RAEB -T >RAEB >RA。结论 :及时有效的治疗可以控制病情发展 ,推迟或延缓急性白血病 (AL)的发生 ,延长患者的生存期。RA、RAS生存期明显长于RAEB -T ,转白率明显低于RAEB -T ,有显著性差异 (P <0 .0 5 )。
Objective:To study factors on treatment effect, transformation and long-term survival of different type of MDS.Methods:To analyse treatment results, disease development, transformation, long-term survival and death reasons of various type of MDS.Results:RA and RAS have better predictive results than other types.The worst predictive results was RAEB-T and that of RAEB was between RA, RAS and RAEB-T. They had high rate to convert into leukemia. The leukemia conversion rate was RAEB-T>RAEB>RA.Conclusion:Timely and effective treatment could control disease development ,delay acute leukemia occurrence and prolong patients survival time.RA and RAS have a significantly long-term survival and lower acute leukemia conversion rate than RAEB-T(P<0.05).
出处
《西北国防医学杂志》
CAS
2002年第3期197-199,共3页
Medical Journal of National Defending Forces in Northwest China
关键词
骨髓增生异常综合征
白血病
病态造血
Myelodysplastic disorder syndrome
Leukemia
Morbid hemocytogenesis