白介素-6对老年原发性肺癌患者5年生存影响的初步观察

Preliminary observation on the influence of IL-6 on the aged patients of primary lung cancer for 5 years

目的 :探讨白细胞介素 - 6 (IL - 6 )在老年肺癌患者手术前后血清以及肺癌组织和肺周边组织含量的变化对患者 5年生存的影响。方法 :2 4例确诊为原发性肺癌的患者 ,取术前和术后血清以及手术中肺癌及肺周边组织标本进行IL - 6检测 ,并观察 5年生存情况。结果 :5年内死亡 9例 ,其中 5例死亡原因为肿瘤复发或转移 ,老年肺癌患者IL - 6的水平在肺癌组织中(8.944± 3.6 82 μg·L-1)显著高于肺周边组织 (6 .0 6 2± 3.0 87μg·L-1) ,老年组与非老年组差异显著 (P <0 .0 5 ) ;老年存活组IL- 6水平在肺癌组织 (8.794± 4.16 3μg·L-1)和肺周边组织中 (6 .2 78± 2 .2 2 6 μg·L-1)均高于老年死亡组 ,并且各组中IL - 6的水平在肺癌组织较肺周边组织有显著差异性 (P <0 .0 5 )。结论 :老年存活的原发性肺癌患者其IL -

Objective:To observe the influence of IL-6 on the aged patients of primary lung cancer for 5 years. Methods:Both of the IL-6 level in serum before and after operation and the IL-6 level in lung cancer and peripheral lung tissue were examined. All patients were followed for 5 years.Results:9 deaths occured in 5 years, 5 of them died from recurrenc or metastases. The IL-6 level in lung cancer (8.944±3.682μg·L -1) was higher than that in peripheral lung tissue ( 6.062±3.087 μg·L -1),and there was significant difference between the aged group and non-aged group (P<0.05). The IL-6 level in lung cancer (8.794±4.163 μg·L -1)and the peripheral lung tissue (6.278±2.226μg·L -1)in the survivor group was obviously higher than that in the death group.Conclusion: The increase of IL-6 level in primary lung cancer and the peripheral lung tissue has influence on the aged patients' survival.