喉部鳞癌p27、ki-67的表达

Expression of p27 and ki-67 in Laryngeal Squamous Cell Carcinoma

目的 :研究p2 7、ki 6 7在喉鳞癌中的蛋白表达水平及其临床意义。方法 :应用免疫组织化学S P法检测p2 7蛋白、ki 6 7抗原在 5 2例喉鳞癌以及 18例癌旁组织中的表达状况。结果 :p2 7蛋白在喉鳞癌中表达阳性率 (5 7.7% )低于癌旁组织 (88.9% ) ,P <0 .0 5 ;p2 7的表达与喉鳞癌患者肿瘤T分级和临床分期呈显著负相关 ,与肿瘤部位、肿瘤分化程度、颈淋巴结转移无关。ki 6 7抗原在喉鳞癌中表达阳性率 (5 5 .8% )高于癌旁组织 (0 % ) ,P <0 .0 1;ki 6 7的表达与喉鳞癌患者肿瘤分化程度呈显著正相关 ,与肿瘤部位、T分级、临床分期、颈淋巴结转移无关。p2 7与ki 6 7的表达在喉鳞癌中无负相关关系。结论 :p2 7蛋白表达可为正确判断肿瘤T分级、临床分期提供新的依据 ;而ki 6 7抗原表达则可为正确判断肿瘤分化程度提供新的依据 。

Objective:To examine the correlation between the expression of p27 protein and ki 67 antigen and to study their clinical significance in the laryngeal squamous cell carcinoma. Methods:The expression of p27 protein and ki 67 antigen in 52 cases of laryngeal squamous cell carcinoma and 18 cases of para carcinoma tissue were detected by by immunohistochemical method. Results: p27 protein positive expressive rate in the laryngeal squamous cell carcinoma (57.7%) was lower than that in the para carcinoma tissue (88.9%),P<0.05. The expression of p27 protein was inversely correlated with T classification and clinical staging,but not correlated with tumor site,tumor grade and cervical lymph node metastasis. Ki 67 antigen positive expressive rate in the laryngeal squamous cell carcinoma (55.8%) was higher than that and in the para carcinoma tissue (0%),P<0.01.The expression of ki 67 antigen was positively correlated with tumor grade;but not correlated with tumor site,T classification,clinical staging and cervical lymph node mestastasis. No inverse correlation had been noted between the expression of p27 and ki 67. Conclusion:The expression p27 protein and ki 67 antigen respectively are able to provide new evidence for determining tumor T classification,clinical staging and tumor grade. They all have special clinical meaning.