胃癌的分离比及遗传度估算

Study on Mode of Inheritance and Heritability of Gastric Cancer

目的:了解遗传因素在胃癌病因中所起的作用。方法:对江苏省胃癌相对高发区金坛市和淮安市的182个先证家系和241个对照家系作分离比和遗传度估算。结果:病例组中有胃癌家族史的比例(22.53%)显著高于对照组(10.79%)(P<0.01),以Li-Mantel-Gart法估计胃癌性状在同胞中的分离比为(14.26±1.40)%,Falconer回归法计算胃癌遗传度为(27.62±4.95)%。结论:胃癌的遗传方式为多基因遗传,遗传因素在胃癌的发生过程中起着一定的作用。

Objective: To evaluate synthetically the role of genetic factor in et iology of gastric cancer. Mhethods:A population-based case control study was c onducted in Jintan and Huai'an counties,two high-risk areas in Jiangsu Provinc e,to analyze heritability and mode of inheritance of gastric cancer (GC). Resul ts:182 proband ancestries and 241 control ancestries were selected for the stud y. The positive family history of GC in probands (22.53%) was higher than that in controls (10.79%)(P< 0.01). The segregation ratio of GC estimated by Li-Man tel-Gart was (14.26±1.40%),which was significantly lower than 0.25. Heritabi lity in the first-degree relatives of probands was 27.62%(male,22.94%;femal e,35.28%) using Falconer model of susceptible threshold value. Conclusion:GC did conform to the characteristic of polygenic inheritance,and genetic agent pl ayed a part in occurrence of GC.