甲亢和甲减患者血清瘦素水平分析

Comparison of Serum Leptin Levels in the Patients with Hyper-and Hypothyroidism

目的:初步探讨瘦素与甲状腺疾病之间的联系,及其与垂体-甲状腺轴之间的相互作用。方法:正常对照组、甲亢、甲减患者清晨空腹取血,磁酶联免疫分析法和SerozymeI系统测定游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、促甲状腺激素(TSH)。瘦素水平采用DSL公司的酶免疫测定试剂盒。结果:与正常对照组相比,甲亢患者TSH显著减低,FT3、FT4显著升高,瘦素水平没有显著变化;甲减患者TSH显著升高,FT3、FT4显著降低,瘦素水平明显升高。男女两性的瘦素水平在正常组、甲亢组差异有显著性,而在甲减组差异不显著。结论:下丘脑-垂体-甲状腺轴和瘦素共同参与机体的进食、体重、能量代谢调节。血清瘦素水平与下丘脑-垂体-甲状腺轴的调节有关,与甲状腺疾病之间也存在着某种相关性。

Objective:To investigate the relationship between leptin and hypop hsis-thyroid axis,and the roles of leptin in the pathophysiology of thyroid di seases.Methods:Hyperthyroidism,hypothyroidism,and volunteers as control,were recruited in this study.Serum thyroid-stimulate hormone(TSH),free T3 and free T4(FT3 and FT4),were measured with the method of magnetic antibody immunoassay .Leptin level was measured with the method of EIA. Results:Compared with contro l group,serum level of TSH in the hyperthyroidism group was significantly low, FT3 and FT4 were significantly high,while there was no difference in serum leve l of leptin.Serum level of TSH in hypothyroidism group increased significantly , FT3 and FT4 decreased significantly. The serum level of leptin in hypothyroidis m group was significantly higher than that in the control group. In euthyroid an d hyperthyroid groups,there was significant difference between male and female of serum leptin,and no relations in hypothyroidism group. Conclusion:Hypothala mus-pituitary-thyroid axis and leptin play an important role in regulating ing estion,weight and energy metabolism.Our data suggested that there was a relatio nship between leptin and thyroid diseases,which confirmed the hypothesis that l eptin and Hypothalamus-pituitary-thyroid axis interacted on each other.