Investigation of the interaction of polyamidoamine dendrimers with nicotinic acid as solubility enhancer 被引量：1

Investigation of the interaction of polyamidoamine dendrimers with nicotinic acid as solubility enhancer

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摘要 ObjectivePolyamidoamine(PAMAM) dendrimers enhance the solubility of nicotinic acid. MethodsPAMAM dendrimers of generation 1 to 6 were prepared and the effect of pH and concentration of the dendrimers on the solubility enhancement of nicotinic acid was investigated. ResultsThe pH and concentration of the dendrimers influence the solubility enhancement of nicotinic acid. Conclusions Electrostatic interaction between the carboxyl group of the nicotinic acid and the amine groups of the dendrimers is involved. ObjectivePolyamidoamine(PAMAM) dendrimers enhance the solubility of nicotinic acid. MethodsPAMAM dendrimers of generation 1 to 6 were prepared and the effect of pH and concentration of the dendrimers on the solubility enhancement of nicotinic acid was investigated. ResultsThe pH and concentration of the dendrimers influence the solubility enhancement of nicotinic acid. Conclusions Electrostatic interaction between the carboxyl group of the nicotinic acid and the amine groups of the dendrimers is involved.

作者 YELing PIAODong－xu 等

机构地区 DepartemtnofChemistry ChinaRehabilitationResearchCenter

出处《中国康复理论与实践》 CSCD 2002年第5期294-295,共2页 Chinese Journal of Rehabilitation Theory and Practice

关键词疏水性药物烟酸助溶剂 PAMAM枝蔓聚合物相互作用 nicotinic acid PAMAM dendrimer solubility enhancement

分类号 R944.9 [医药卫生—药剂学]

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参考文献5

1[1]Tomalia DA,Baker H,Dewald J.A new class of polymers: starburst-dendritic macromolecules[J].J Polymer,1985,17(1):117-132.
2[2]Tomalia DA,Naylor AM,Goddard Ⅲ WA.Starburst dendrimers: molecular-level control of size,shape,surface chemistry,topology,and flexibility from atoms to macroscopic matter[J].Angew Chem Int Ed Engl,1990,29:138-175.
3[3]Kukowska-Latallo JF,Bielinska AU,Johnson J,et al.Efficient transfer of genetic material into mammalian cells using starburst polyamidoamine dendrimers[J].Proc Natl Acad Sci USA,1996,93:4897-4902.
4[4]Malik N,Wiwattanapatapee R,Klopsch R,et al.Dendrimers: relationship between structure and biocompatibility in vitro,and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo[J].J Controlled Release,2000,65: 133-48.
5[5]Zhuo RX,Du B,Lu ZR.In vitro release of 5-fluorouracil with cyclic core dendritic polymer[J].J Controlled Release,1999,22; 57(3): 249-57.

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Investigation of the interaction of polyamidoamine dendrimers with nicotinic acid as solubility enhancer 被引量：1

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