突发性聋患者血管紧张素系统活性检测的临床意义

Clinical implications of the activity of reninangiotensin system in sudden hearing loss

目的 探讨肾素一血管紧张素系统（ＲＡＳ）的活性与突发性聋的发生及预后的相关性。方 法 应用放射免疫法测定无高血压病史的突发性聋患者治疗前的血浆肾素活性（ＰＲＡ）、血管紧张素 Ⅱ （ＡｕｇⅡ）水平，并与正常听力的健康者为对照组比较。结果 治疗无效组的突发性聋患者在治疗前其 ＰＲＡ、ＡｕｇⅡ水平与对照组差异有显著性意义（Ｐ＜０．０５）；治疗有效组的突发性聋患者在治疗前其 ＰＲＡ、ＡｕｇⅡ水平与对照组差异无显著性意义（Ｐ＞０．０５）。结论 突发性聋患者中血管紧张素系统活性 升高者用血管扩张剂治疗效果欠佳。而血管紧张素系统活性正常者用血管扩张剂治疗有效。突发性聋患 者治疗前的ＲＡＳ的活性与其予后有关。

Objective To investigate the clinical implications of the plasma activ-ity of renin-angiotensin system in patients with sudden hearing loss(SHL). Methods The levels of plasma renin activity (PRA) and angiotensin 0I content (Ang I ) were quantitatively determined by radioimmunoassay in 31 cases of SHL before and after treatment, and the results were compared with that in 15 cases as controlling with nor-mal hearing and being in the same age region. Results Patients were divided into two sub-groups based on their response to the therapy, i. e. effective group and ineffective one. There were significantly higher levels of PRA and Ang I in ineffective group than in effective one (P<0. 05), and no significant differences were seen between effective group and normal controlling one in PRA and Ang II levels （P>0. 05). Conclusion Angioectatic drugs may be ineffective for SHL cases with increased activity of rein-an-giotensin system and be effective for those with normal activity of the system.