咳喘宁胶囊对慢性支气管炎大鼠支气管及肺组织病理形态学的影响

Effect of Kechuanning Capsule on Pathonorphological Change of Lung Tissue and Bronchi on Chronic Bronchitic Rats

目的 :观察咳喘宁胶囊对实验性慢性支气管炎病理形态学的影响。方法 :用改良烟熏法复制大鼠慢性支气管炎模型 ,实验分组为模型组、咳高组、咳低组、桂龙组 ,并设不加处理的正常对照组。以高、低剂量咳喘宁和桂龙咳喘宁进行干预 ,取材后 ,常规HE染色 ,光镜下观察。结果 :慢支模型细支气管管腔增大 ,管壁大量纤维组织增生 ,明显增厚 ,部分上皮细胞坏死脱落 ,周围可见大量以淋巴细胞为主的慢性炎细胞浸润。肺泡上皮细胞部分坏死脱落 ,肺泡间隔明显增宽 ,伴有慢性炎细胞及少量中性粒细胞浸润 ,肺泡有不同程度的纤维化 ,小静脉有淤血现象。咳高组可见细支气管黏膜上皮完整 ,无明显细胞水肿。支气管管腔无明显扩张 ,管壁无明显增厚 ,伴见少量纤维组织及少量淋巴细胞浸润。肺泡间隔稍增宽 ,少量淋巴细胞浸润。咳低组则无明显改变。结论 :咳喘宁胶囊可改善支气管、肺组织损伤程度 。

Objective: To observe the effect Kechuanning on Pathonorphological Change of Lung tissue and Bronchi on Chronic Bronchitic Rats.Method: Chronic bronchitis model was induced with refined smoke-fumigating method. There were model group, high dose group with Kechuanning, low dose group with Kechuanning, group with Guilong and blank control group. The tissues were observed under light microscope with HE staining. Result: In the model group, the cavities of brochioles were enlarged, the dissepiments were thickened due to fibrous proliferation, and some epithelial cells necrosed and abscised accompanied with inflammatory infiltration mainly of lymphocytes. Some alveolar epitheliums necrosed and abscised, alveolar septum were broadened significantly accompanied with some neutrophilic granulocytes infiltration, and alveoli were fibrosed accompanied with small vein congestion. In the high dose group, such damages were alleviated while in the low dose group, there was no significant change. Conclusion: Kechuanning Capsule can alleviate the damages of Bronchi and lungs and treat chronic bronchitis effectively.