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糖尿病患者血浆神经肽Y的变化 被引量:1

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摘要 目的 探讨糖尿病患者血浆神经肽Y水平变化的意义。方法 采用同位素放射免疫分析法 ,对 38例糖尿病血糖控制良好组 ,对 34例糖尿病血糖控制不良组及 30例正常对照组进行血浆NPY的检测。结果 糖尿病血糖控制不良组血浆NPY含量 (32 1.8± 5 0 .1pg/ml)明显高于血糖控制良好组(190 .2± 49.6pg/ml)及正常对照组 (15 2 .8± 37.6 pg/ml) ,血糖控制良好组血浆NPY含量高于正常对照组。结论 糖尿病患者血浆神经肽Y水平升高 ,尤其血糖控制不良组明显 ,提示检测血浆NPY含量在一定程度上有助于对糖尿病发病机制上的进一步认识。
出处 《齐齐哈尔医学院学报》 2001年第12期1358-1358,共1页 Journal of Qiqihar Medical University
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  • 1(车卜)启德,王宪.神经肽Y对心血管的作用及其病理生理意义[J].生理科学,1989,9(1):6-10. 被引量:24
  • 2Wang ZL, Bennet W M, Wang RM, et al. Evidence of a paracrine role of neuropeptide Y in the regulation of insulin release from pancreatic islets of normal and dexamethasone- treateed rats[J ]. Endocrinology, 1994, 135:200 - 206
  • 3Mol tz HT, MCDOCALD JK. Neuropeptide Y. Direct and indirect action on insulin secretion the rat[J ]. Peptides 1985, 6:1 155
  • 4Marsh DJ, Hollepeter GK, Afer KE, et al. Role of the Y5 neuropeptide Y receptor in feeding and obesity[ see comments] [J ].Nat Med, 1998,4:718- 721
  • 5Billington CT,Briggs JE, et al. Effects of intracerebroven tricolor injection of neuropeptide Y on energy metabolism[J ]. Am T Physiol, 1991,260:321 - 327

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  • 1李军,李秀钧,张杰,罗梅,周桥,赵桂芝.糖耐量受损大鼠胰岛α细胞胰高血糖素及神经肽Y的表达[J].中华内分泌代谢杂志,2004,20(3):185-189. 被引量:31
  • 2马健.神经肽Y与肥胖的研究进展[J].心血管病学进展,2004,25(B12):91-93. 被引量:3
  • 3任伟,张素华,倪银星,吴静.2型糖尿病家系神经肽Y血浆水平研究[J].中国误诊学杂志,2005,5(11):2003-2005. 被引量:2
  • 4范艳萍,石建华,项平.神经肽Y结构和作用[J].实用全科医学,2007,5(6):537-538. 被引量:21
  • 5King PA, Horton ED, Hirshman MF, et al. Insulin resistance in obese Zucker rat(fa/fa) skeletal muscle is associated with a failure of glucose transporter transloeation [ J ]. J clin Invest, 1992, 90: 1568-1575.
  • 6W. M. BENNET, Z. L. WANG, et al. Presence of neuropeptide Y and its messenger ribonucleic acid in human islets evidence for a possible paracrine role[J ]. The Endocrine Society, 1996, 81:2117- 2120.
  • 7Leibowitz SF, Sepiashvili K, Akabayashi A, et al. Function of neuropeptide Y and agouti-related protein at weaning: relation to corticosterone, dietary carbohydrate and body weight [ J ]. Brain Research, 2005, 1036 : 180-191.
  • 8Zarjevski N, Cusin I, Vettor R, et al. Chronic intracerebroventricalar neuropeptide Y administration to normal rats mimics hormonal and metabolic changes of obesity [ J ]. Endocrinoology, 1993, 133 : 1753-1758.
  • 9Sainsbury A, Schwarzer C, Couzens M, et al. Y2 receptor deletion attenuates the type 2 diabet-ic syndrome of ob/ob mice[J ]. Diabetes, 2002, 51(12) :3420-3427.
  • 10Shin MS, Kim H, Chang HK, et al. Treadmill exercise suppresses dabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats [ J ]. Neuroscience Letters, 2003, 346 (3) : 157- 160.

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