电针对高血压血管性痴呆大鼠的疗效及对脑AVP的影响

Effect of electroacupuncture on vascular dementia and AVP in brain of rats

目的探讨电针对血管性痴呆 (VD)大鼠的疗效及对脑精氨酸加压素 (AVP)的影响。方法将 30只大鼠制成肾性高血压 (RHR)后再造成脑反复缺血拟VD ,随机分为模型组、电针组和药物组 (用氢化麦角碱 ,DHET)各 10只 ,共治疗 2 8天。治疗后均以水迷宫检测学习记忆行为情况 ,并检测脑AVP的含量。结果模型组水迷宫潜伏期明显长于电针组和药物组 (P <0 .0 5—0 .0 0 5 ) ,药物组长于电针组 (P <0 .0 5— 0 .0 0 5 )。在额叶 ,电针组和药物组AVP含量均显著高于模型组 (P <0 .0 1,P <0 .0 5 ) ;在纹状体 ,电针组AVP含量高于药物组 (P <0 .0 5 ) ,而在海马、颞叶 ,3组的AVP含量无显著性差异。结论电针能改善VD大鼠学习记忆行为 ,提高脑AVP的含量并使之重新分布 ,其作用优于DHET。

ObjectiveTo probe the effect of the electroacupuncture on vascular dementia(VD) and content of arginine vasopressin(AVP) in brain of rats. Methods30 Sprague Dawley rats were made renal hypertension(RHR) by the kidney arteries pinched with silver clip.After 42 days, their bilateral common carotid arteries were blocked repeatedly to cause cerebral ischemia.The Hypertension Vascular Dementia model was made. Then they were divided into model group,electroacupuncture group and medicine group(Dihydroergotoxine,DHET) with 10 in each group. The course was 28 days. The ability of learning and memorizing was observed by water maze, and the content of AVP in brain was detected after treatment. ResultsThe latent period of the electroacupuncture group and medicine group was shorter than that of the model group( P<0.05-0.005), and that of the electroacupuncture group was shorter than medicine group( P<0.05-0.005). In frontal lobe, the contents of AVP in the electroacupuncture and medicine groups were higher than that of model group( P<0.01, P<0.05), and the electroacupuncture group was higher than medicine group in striatum ( P<0.05). Conclusions It indicated that electroacupuncture therapy can promote the ability of learning and memorizing and enhance the content of AVP in the brain of VD rats. It's therapeutic effect is better than that of DHET.