颈髓损伤患者免疫功能状态的临床观察

The clinical study of immune state in cervical spinal cord injury

目的观察颈髓损伤患者T淋巴细胞亚群及免疫球蛋白的变化并探讨其临床意义。方法对 36例颈髓损伤患者于康复治疗前后检测外周血T细胞亚群及免疫球蛋白水平 ,并与正常对照组比较。结果康复治疗前颈髓损伤患者CD3 + 、CD4 + 、CD4 + /CD8+ 及IgG水平均较对照组降低 (P <0 .0 5 ) ,治疗后CD3 + 及CD4 + /CD8+ 改善 (P <0 .0 5 )。完全性脊髓损伤患者免疫功能抑制较不完全性损伤更严重。结论颈髓损伤患者细胞及体液免疫功能处抑制状态 ,完全性脊髓损伤免疫功能抑制更严重。

ObjectiveTo measure the level of T lymphocyte subsets and immunoglobulin in cervical spinal cord injury. Methods36 cases with cervical spinal cord injury were measured in T lymphocyte subsets and immunoglobulin of vein blood before and after the rehabilitation therapy. By comparing with control group, the state of immune functional in the injury was analyzed.ResultsThe cellular and humoral immune were inhibited distinctly. The level of CD 3 +, CD 4 +, CD 4 +/ CD 8 + and IgG of TBI group were lower than the level of control group. The CD 3 + and CD 4 +/ CD 8 + were improved after treatment. The immune state of complete injury was inhibited more seriously than incomplete injury. ConclusionsThe cellular and humoral immune of cervical spinal cord injury were inhibited. The more seriously of the injury, the more inhibited of immune function.