小儿腹泻病血胃泌素、胃动素和生长抑素含量变化与胃肠运动功能的关系

Relationship Between Alteration of Gastrin,Molilin and Somatostation in Blood and Function of Gastrointestinal Motility in the Children With Deferred & Chronic Diarrhea Diseases.

【目的】 探讨小儿迁延性及慢性腹泻病血中胃泌素 (GAS)、胃动素 (MOT)和生长抑素 (SS)的变化情况和它们与胃肠动力紊乱的关系。 【方法】 应用放免法对 2 8例迁延性及慢性腹泻病患儿治疗前和恢复期晨空腹及餐后 1小时的血GAS、MOT和SS水平进行测定 ,并用实时超声显像法对他们餐后的胃运动及胃排空进行研究 ,同时与 2 2例正常儿童作比较。 【结果】 患儿治疗前空腹和餐后的血清GAS和血浆MOT水平高于恢复期和对照组 (P <0 .0 0 1) ;空腹的血浆SS水平尽管前者亦高于后两者 (P <0 .0 5 ) ,但餐后差异无显著性 (P >0 .0 5 ) ;患儿治疗前空腹和餐后的GAS/SS和MOT/SS比值明显大于恢复期和正常儿童 (P <0 .0 5 )。患儿病期的胃体蠕动频率 (FB)、胃窦收缩频率 (FA)和 3 0、60、90及12 0分钟胃排空率 (GER)明显增快 ,而且 12 0分钟GER与空腹和餐后的血浆SS水平在各组都呈负相关 ,与GAS/SS和MOT/SS的比值则呈正相关。 【结论】 迁延性及慢性腹泻小儿血中的GAS和MOT水平升高 ,GAS/SS和MOT/SS比值增大 ,而且GAS、MOT和SS分泌失调与胃肠动力异常有密切的关系。

To investigate the alteration of gastrin(GAS),motilin(MOT) and somatostatin(SS) in blood and their relationship with disorder of gastrointestinal motility in the children with deferred and chronic diarrhea diseases. The serum or pasma levels of GAS,MOT and SS 1 hr before and after having test breakfast of 28 children with deferred and chronic diarrhea diseases,before treated and after their recovery from disease were measured with the radioimmunoassay,and the gastric motility and gastric emptying rate after having test breakfast were studied with real time ultrasonography,as compared with those of 22 normal controls. The precibal and postcibal levels of serum GAS and pasma MOT in the children with diarrhea before treated were higher than those after their recovery from disease and those of normal controls( P <0.01).The precibal levels of SS of the former were also higher than those of the latter two( P <0.05),but there was not significant difference in the postcibal ones( P >0.05).The precibal and postcibal values of GAS/SS and MOT/SS in children with diarrhea before treated were bigger than those after their recovery from disease and those of normal controls( P <0.05).The peristalsic frequency of gastric body(FB),contractive frequency of antrum(FA) and gastric emptying rates(GER) at 30,60,90 and 120 min.of the children with diarrhea increased obviously.There were the negative correlations between GER at 120 min.and the precibal and postcibal levels of plasma SS in each of the groups,and the positive correlation between them and the valus of GAS/SS and MOT/SS. [Conclusions] In children with deferred or chronic diarrhea diseases,the levels of GAS and MOT in blood were obviously high,and the values of GAS/SS and MOT/SS also increase.There was a close relationship between the disordered secretion of GAS,MOT and SS,and the disorder of gastrointestinal motility.