南京地区TTV分子流行病学调查

MOLECULAR EPIDEMIOLOGY STUDY ON TRANSFUSION TRANSMITTED VIRUS IN NANJING

目的 :探讨经血传播病毒 (TTV)在南京地区分子流行学状况及TTV可能的传播途径。方法 :选择各型病毒性肝炎 975例 ,献血员 30例 ,慢性肾功能衰竭长期血透者 1 50例及健康者 32例作为研究对象 ,用n -PCR法检测各种人群中 (TTVDNA)的感染情况。并研究TTVDNA阳性与输血的关系。结果 :在各种人群中TTVDNA的检出率分别为非甲～庚型肝炎 2 2 % ,病毒性肝炎 1 3 .9% ,献血员 33 .3 % ,长期血透者 2 7.3 % ,健康人 9.4% ,1 36例TTVDNA阳性病毒性肝炎患者仅 1 9.9% (2 7/ 1 36)有输血史。结论 :献血员及其它经常接触血制品的人群是TTV感染的高危人群 ,输血是TTV感染的途径之一 。

Objective:To perform the study of molecular epidemiology on transfusion transmitted virus (TTV) and other ways of TTV transmission in addition to blood transfusion. Methods:erum samples were selected including 975 from virus hepatitis patients,30 from blood donors,150 from hemodialysis patients,32 from healthy people.TTV DNA was analyzed in 1187 serum specimens with nested PCR.The relation of TTV DNA and transfusion was also analyzed.Results:The positive rates of TTV DNA among non hepatitis A to G,virus hepatitis patients,blood donors,hemodialysis patients and healthy people are 22%,13.9%,33.3%,27.3%,9.4%.Only 27 patients (19.9%) received blood or blood products in 136 TTV DNA positive virus hepatitis.Conclusions:Blood donors and hemodialysis patients are the high risk population of TTV infection.Blood transfusion can be a way of virus spreading,potentially there are other ways of virus transmission in addition to blood transfusion.