乙型丙型肝炎、EB病毒双重感染与病程迁延关系(附16例报告)

The Relatioship Between the Patients of Hepatitis B or C With or Without Superinfection of EB Virus and the Clinical Course (16 Cases Report)

目的 观察EB病毒 (EBV)重叠感染是否与乙型丙型肝炎病程迁延有关。方法 观察 16例慢性乙型丙型肝炎重叠EB病毒感染患者 (观察组 )肝功能持续异常时间 (病程 ) ,并以同期住院的 16例无合并EBV感染的慢性乙型丙型肝炎患者作对照组。结果 两组症状、血象相仿 ,观察组病程 (2 0 3 19± 16 8 2 9)d ,明显长于对照组 (6 4 6 3± 5 6 6 2 )d ,差异非常显著 (P <0 0 1) ;另选 4例乙型肝炎重叠EBV感染者试行抗病毒治疗 ,2例以苦参素治疗者肝功能复常时间是半年、7月 ,另 2例以拉米呋啶治疗者肝功能复常时间为 15d、2 5d。结论 乙型丙型肝炎重叠EBV感染确是其病程迁延的原因之一 。

Objective In order to investigate the relationship between EB virus superinfection and HBV or HCV persistent .Methods 16 cases of EBV with superinfected HBV or HCV as experimental group and 16 HBV or HCV infected patients without EBV infection with the similar clinical symptoms and blood test results,as control group,both were followed up for one year. Results The disease course of experimental group was longer than the control group(203 19±168 29 days vs 64 63±56 62 days,(P<0 01),Liver function test was recovered to normal at the beginning of study.6 months and 7 months later in the two patients treated with oxymatrine, and at the beginning of study,15 days and 25 days later in the two patients treated with lamivudine respectively. Conclusion Our data suggested that EB virus superinfection could play an important role on the persistence of HBV or HCV infection and lamivudine demonstrated to be effective to clear HBV or HCV in the patients superinfected with EB virus, therefore the lamivudine migth short the course of the disease, diminish the chance of persistent HBV or HCV superinfection.