肺心病患者血清Ⅲ型前胶原、Ⅳ型胶原及脯氨酸肽酶含量的改变

The content changes of the blood serum procollagen Ⅲ, collagen Ⅳ and the prolidase in patients with pulmonary heart disease

目的 研究肺心病患者血中Ⅲ型前胶原 (PCⅢ )、Ⅳ型胶原 (CⅣ )及脯氨酸肽酶 (PLD)的含量变化及临床意义。方法 对 30例肺心病患者和 30例健康人采用放射免疫分析法检测血清中PCⅢ及CⅣ的含量 ;用分光光度比色法检测血清中PLD含量。结果 肺心病患者血清中PCⅢ及CⅣ含量明显增高 ,同时PLD含量亦增加 ,与健康对照组比较 ,差异有高度显著性 ,P <0 .0 1。结论 肺心病患者血清PCⅢ、CⅣ及PLD的水平可作为反映肺血管重建和肺动脉高压的参考指标。

Objective To investigate the content changes and clinical significance of the blood serum procollagen Ⅲ (PCⅢ), collagen Ⅳ (CⅣ) and the prolidase (PLD) in patients with pulmonary heart disease. Methods A radio-immunity analysis method was used to measure the content of blood serum PCⅢ and CⅣ in 30 patients with pulmonary heart disease and in 30 healthy individuals, and a spectrophotometry colorimetric method was used to measure the content of blood serum PLD. Results The content of blood serum PCⅢ and CⅣ increased significantly in patients with pulmonary heart disease, and the content of PLD also increased, in comparison with the healthy control group, the difference was significant, P<0.01. Conclusions The levels of blood serum PCⅢ, CⅣ and PLD could be taken as the reference indexes to reflect the restoration of pulmonary vessels and the pulmonary hypertension.