一个与人类待定肿瘤抑制基因同源的水稻基因的分离(英文)

Isolation of a Rice Gene Homologous to the Human Putative Tumor Suppressor Gene QM

从水稻基因文库中筛选到一个与人类待定肿瘤抑制基因QM同源的基因 ,命名为OSQM 2 .该基因片断长为 3.1kb ,编码一个具有 184个氨基酸的高度碱性的蛋白质 .与其他已知QM基因相比 ,该基因具有一个非常特殊的启动子 ,包含许多在植物中已发现的与抗逆有关的顺式作用因子 ,如 :“G盒” ,“DRE盒” ,“MYC盒”等 ,故而该基因有可能是一个新的受环境胁迫因子诱导的基因 .

A gene homologous to the human putative tumor suppressor gene QM was isolated from rice genomic library. It was designated OS QM 2. The sequence was about 3.1 kb long and encoded a highly basic protein of 184 amino acids. It has a very special promoter region compared with other known QM genes. Many known cis acting elements such as 'G box', 'DRE' box, 'MYC' box can be found in its promoter region, so it is a putative new stress inducible gene. Southern hybridization indicated that it existed in rice genome as a single copy gene.