山楂及山楂黄酮提取物调节大鼠血脂的效果研究

Effect of hawthorn and hawthorn flavonoids extract on rats with hyperlipidemia

为研究山楂和山楂黄酮调节血脂的效果 ,本课题观察了山楂黄酮和山楂汁对高脂血症大鼠血清脂质和肝脏脂水平的影响。大鼠高脂饲料含有 1%胆固醇、10 %猪油、10 %蛋黄粉和 79%基础饲料。结果显示第五周末实验结束时 ,山楂黄酮和山楂汁使高脂血症大鼠血清甘油三酯、肝脏甘油三酯明显降低 (P <0 0 5 ) ,山楂黄酮和山楂汁使肝脏胆固醇明显降低 (P <0 0 5 ) ,但两种受试物都未降低血清胆固醇。本研究提示山楂和山楂黄酮对高脂血症大鼠的甘油三酯代谢具有良好的改善作用 。

To explore the lipolipidemic effect of hawthorn and hawthorn flavonoids extract,the effects of hawthorn and hawthorn flavonoids extract on rats with hyperlipidemia were observed.The semipurified diet for rats is composed of 1% cholesterol,10% lard,10% yolk powder and 79% basic diet.The levels of serum TC,TG,HDL\|C,hepatic cholesterol and hepatic triglyceride were assayed.After 5 weeks,the levels of serum triglyceride and hepatic triglyceride in groups receiving hawthorn flavonoids and hawthorn drinks were lower than that of control significantly.The levels of hepatic cholesterol were lower in groups treated with hawthorn flavonoids and hawthorn drinks significantly.The result suggests that hawthorn and hawthorn flavonoids could improve the triglyceride metabolism but not the cholesterol metabolism.