杏丁预处理对实验性兔急性心肌缺血的保护作用

PROTECTIVE EFFECTS OF PRETREATMENT WITH XINGDING ON RABBITS WITH ACUTE MYOCARDIAL ISCHEMIA

目的 探讨杏丁预处理对兔急性心肌缺血的保护作用。方法 2 0只健康兔随机分为对照组与杏丁预处理组 (结扎冠脉前3d ,每d予以杏丁 5ml/kg经耳缘静脉缓慢注入 ) ,结扎冠状动脉左旋支造成急性心肌梗死模型 ,分别测定结扎前及结扎后 1 5、60、1 2 0min的左心功能 ,于冠脉结扎 1 2 0min后取心脏 ,采用伊文斯蓝和N -BT染色法测量心肌缺血范围和心肌梗死范围。结果 与对照组相比 ,杏丁预处理组心肌缺血及心肌梗死范围明显缩小 (P分别 <0 .0 5、0 .0 1 ) ,左室功能也更好 (P <0 .0 1 )。结论 杏丁预处理对急性心肌缺血具有明显保护作用 ,可缩小心肌缺血和梗死范围 ,改善心功能。

Objective To explore the protective effects of pretrestment with Xingding on rabbits with acute myocardial ischemia. Methods 20 healthy rabbits were randomly divided into control group and Xingding pretreatment group (Xingding of 5ml/kg per day was infused via marginal ear vein for 3 days before ligating coronary artery). The left circumflex branch of coronary (LCX) was ligated to develop acute ischemic model. The left ventricular function was measured 15min, 60min and 120min before and after the ligation respectively. 120min after LCX ligation, the hearts were harvested for determining the ischemia size and the infarction size by dual staining with Evan's blue dye and N-BT. Results Compared with the control group, the Xingding pretreatment group showed that the ischemic size and the infarct size were significantly reduced (P< 0.05 and P<0.01 respectively) and the left ventricular function was better reserved (P<0.01). Conclusion Xingding pretreatment can reduce ischemic and infarct size and improve the left ventricular function of the heart undergoing acute myocardial ischemia.