阿托伐他汀与常用调脂药物治疗老年混合型高脂血症的疗效比较分析

Efficacy comparison of atorvastatin,simvastatin,lovastatin+polyunsaturated fatty acid in treatment on aged people with combined hyperlipidaemia

目的 比较他汀类药物阿托伐他汀、辛伐他汀、洛伐他汀单独应用及与不饱和脂肪酸 (Omega - 3)联用 ,治疗老年混合型高脂血症患者的疗效与安全性。方法 10 4例混合型高脂血症患者随机分为 3组 ,即阿托伐他汀组、辛伐他汀组、洛伐他汀 +Omega - 3组 ,治疗 8周 ,观察降脂疗效、不良反应。结果 阿托伐他汀降甘油三酯 (TG)、低密度脂蛋白 (LDL -C)优于辛伐他汀、洛伐他汀与Omega - 3联用 ;升高高密度脂蛋白 (HDL -C)则是辛伐他汀、洛伐他汀与Omega - 3联用优于阿托伐他汀 ;降总胆固醇 (TC)、动脉硬化指数 ((TC -HDL -C) /HDL -C) ,三组无显著差别。TC、TG、LDL -C三项指标达标率三组也极为相近。结论 综合考虑各种因素 ,建议治疗混合型高脂血症患者可首选他汀类药物 ,必要时与不饱和脂肪酸联用 ,全面调节血脂的效果最好。

Objective To evaluate the efficacy and safety of atorvastatin,simvastatin,and lovastatin+unsaturated fatty acid(Omega-3)in treatment on aged people with combined hyperlipidaemia Methods One hundred and four patients with combined hyperlipidaemia were randomizedly divided into 3 groups,atorvastatin,simvastatin,lovastatin with Omega-3,observing efficacy and safety for 8 weeks Results Atorvastatin is superior to simvastatin and lovastatin+Omega-3 in reduction of TG,LDL-C Simvastatin and lovastatin+Omega-3 are better than atorvastatin in elevation of HDL-C Three groups are similar in reduction of TC,(TC-HDL-C)/HDL-C and in the rate of under par on TC,TG and LDL-C Conclusion In general,the statins should be first chosen,and then Omega-3 could be supplemented when necessary in treatment of combined hyperlipidemia is strongly suggested