摘要
目的 研究中药成分青藤碱 (Sin)对吗啡依赖小鼠催促戒断症状的影响。方法 以剂量递增法形成吗啡依赖小鼠模型 ,ipSin 30min后 ,用纳络酮进行催促戒断 ,观察小鼠的戒断反应。结果 ipSin 10mg·kg-1后 ,小鼠的跳跃反应、前爪震颤、体重下降等戒断症状均明显减少或减轻 ,ipSin 30、6 0mg·kg-1可抑制小鼠跳跃、扭体、前爪震颤、“湿狗”样抖动、体重下降等症状。结论 Sin能抑制吗啡依赖小鼠催促戒断症状 。
Aim To study the effects of sinomenine (Sin) on the naloxone-precipitated withdrawal syndrome in morphine dependent mice.Methods Mice were given increasing doses of morphine to produce a physical dependence.Withdrawal syndrome were precipitated by naloxone in 30min after ip Sin.Results At the dose of 10mg·kg -1 ,Sin inhibited jumping reaction,forepaw tremor and body weight loss of mice.At the dose of 30,60mg·kg -1 ,Sin inhibited jumping,wrest body,forepaw tremor,'wet dog'shakes and body weight loss of mice.Conclusion Sin could significantly inhibit withdrawal syndrome in morphine dependent mice and relieve body weight loss of mice.
出处
《解放军药学学报》
CAS
2002年第3期134-136,共3页
Pharmaceutical Journal of Chinese People's Liberation Army