急性CO中毒后迟发性脑病神经元特异性烯醇化酶测定的临床意义

Determination of neuron-specific enolase and its significance in delayed encephalopathy after acute carbon monoxide poisoning

目的 探讨急性CO中毒后迟发性脑病 (DEACMP)患者脑脊液 (CSF)和血清神经元特异性烯酶化酶(NSE)的变化及临床意义。方法 对 49例DEACMP患者均在急性期入院 3d内抽取CSF和血标本进行NSE测定 ,其中 34例于治疗 30d后再次采取标本复查 ,对比分析治疗前后NSE的变化。结果 患者组急性期CSF和血清NSE含量较对照组明显增高 (P <0 .0 0 1) ;治疗后明显下降 (P <0 .0 0 1,P <0 .0 0 5 ) ,与对照组比较差异无显著性 (P >0 .0 5 ) ;患者组CSF和血清NSE呈明显正相关 (r =0 .46 14,P <0 .0 0 1)。结论 CSF和血清NSE测定可作为DEACMP诊断和病情判断的有效指标。

Objective To study cerebrospinal fluid(CSF) and serum levels of neuron specific enolase(NSE) and its clinical significance in delayed encephalopathy after acute carbon monoxide poisoning(DEACMP). Methods Fasting venous blood and CSF in 49 patients with DEACMP were drawn within 3 days after attack, and the NSE levels were measured. Samples were drawn again and measured after 30 days treatment in 34 patients. Results The concentration of NSE in CSF and serum were significantly higher in patients than in controls( P <0.001). The contents of NSE in CSF and serum were obviously lower after treatment than before treatment( P<0.001,P<0.005 ). The NSE levels after treatment showed no significant difference from controls. There were markedly positive correlation between CSF NSE and serum NSE ( r=0.4614,P<0.001 ). Conclusion NSE levels in CSF and serum are useful for the diagnosts and treatment dicators for DEACMP.