饮茶与女性乳腺癌的关系

Association between green tea drinking and breast cancer risk

目的 探讨饮茶和女性乳腺癌的关系。方法 采用以人群为基础的病例对照研究 ,调查上海市 1999年 4月～ 1999年10月间确诊的、年龄在 30岁～ 74岁之间的乳腺癌患者 (n =35 6 )和全人群对照 (n =92 5 )的一般情况、饮食摄入情况、个人生活习惯、疾病及家族史、月经生育史等 ,采用非条件logistic回归模型分析饮茶与女性乳腺癌的关系。结果 以不饮茶的人做参比 ,饮茶者每月消耗的茶叶量按五分位法分组 ,各组的OR值和 95 %可信限分别是 0 .77(95 %CI =0 .4 0～ 1.4 7)、0 .4 9(95 %CI=0 .2 4～ 1.0 0 )、0 .34(95 %CI =0 .15～ 0 .75 )、0 .5 5 (95 %CI =0 .2 7～ 1.12 )、0 .16 (95 %CI =0 .0 5～ 0 .5 4 ) ,趋势检验P <0 .0 1。但未发现乳腺癌的危险性随饮茶年限的延长而下降。进一步分析发现 ,饮茶与乳腺癌的负相关关系仅存在绝经前妇女。在绝经妇女中 ,未能发现茶叶消耗量、总饮茶量以及饮茶时间与女性乳腺癌的负相关关系。结论 饮茶对女性乳腺癌可能具有保护作用 ,此作用可能仅局限在绝经前妇女中。

Objectives To examine the association between green tea drinking and breast cancer risk. Methods We conducted a population based case control study among Chinese women in Shanghai from April, 1999 to October,1999. The study included 356 cases and 925 controls with response rate 87% and 90%. All analyses were conducted separately for all study subjects as well as a subgroup of subjects who reported no recent change in tea consumption. Results The risk of breast cancer significantly reduced with increasing drinking of green tea, with ORs being 0.77(95%CI=0.40～1.47), 0.49(95%CI=0.24～1.00), 0.34(95%CI=0.15～0.75), 0.55(95%CI=0.27～1.12) and 0.16(95%CI=0.05～0.54) for the second to fifth quintile intake of tea compared to non green tea consumption. However, the duration of green tea drinking was not associated with breast cancer risk. The inverse association between green tea drinking and breast cancer risk was only observed for premenopausal women. Conclusion Green tea drinking may protect against the risk of breast cancer. The potential protective effect may only appear in premenopausal women.