肥厚性瘢痕组织中VEGF、ICAM-1、c-fos表达的变化

Expression of VEGF,ICAM-1 and c-fos proteins is increased in hypertrophic scars tissues

目的 检测与血管内皮细胞激活及增生相关的血管内皮生长因子 (VEGF)、细胞间粘附分子 1(ICAM 1)、以及c fos原癌基因在肥厚性瘢痕组织中的表达。方法 采用免疫组化SP方法 ,比较VEGF、ICAM 1、c fos在肥厚性瘢痕、正常瘢痕、正常皮肤组织中的表达。结果 VEGF、ICAM 1、c fos在肥厚性瘢痕中表达皆增强。VEGF、c fos主要表达在表皮、真皮血管、皮肤附属器 ;ICAM 1主要表达在真皮浅层血管、浸润的炎细胞、成纤维细胞。结论 肥厚性瘢痕组织中血管内皮细胞处于一种激活状态 。

Objective To determine the expression of ICAM 1,VEGF, and c fos proteins in hypertrophic scars.Methods An immunohistochemistry Streptavidin Peroxidase technique was performed for detecting the in situ expression of ICAM 1, VEGF, c fos proteins in hypertrophic scars, normal scars, and normal controls skin tissues.Results The expressons of ICAM 1, VEGF and c fos was increased in hypertrophic scars. Increased staining was predominantly associated with the superficial vessels.Conclusion The microvascular endothelial cells in hypertrophic scars were activated.The endothelial cells had a higher proliferating activity.