大剂量病毒唑对流行性出血热患者出血倾向及病死率的影响

Effects of Ribavirin on Haemorrhagic Tendency and Fatality Rate of Patients with Epidemic Haemorrhagic Fever

通过244例EHF患者的大剂量病毒唑双盲对照治疗的研究发现,早期(发热4天以内)大剂量病毒唑的应用能阻断或减轻EHF患者凝血-抗凝血系统的紊乱,促进其恢复,从而明显改善EHF的出血倾向,降低病死率(P<0.05)。进一步证实了大剂量病毒唑在EHF早期应用具有良好的疗效。

This paper reports some findings of the double blind trial of higher dose of ribavirin in 244 EHF patients.Administration of higher dose of ribavirin in the early EHF(4 days or before)can stop or reduce effectively the dysfunctions of coagulation and anticoagulation system,and decrease the haemorrhagic tendency and fatality rate of EHF patient(p<0.05). These further demostrate that higher dose of ribavirin is effective for early EHF.