各种HBsAg阳性人群中抗D型肝炎病毒抗体的研究

Prevalence of Anti-hepatitis Delta Virus Antibody in Various HBsAg Positive Populations

采用Abbott EIA法对各种HBsAg阳性人群血清抗HDV抗体进行了调查,结果在1004份血清标本中检出有18份标本抗HDV抗体阳性,阳性率为1.8%。抗HDV抗体检出率与年龄、性别无关。但在无症状HBsAg携带者、急性乙型肝炎、慢性乙型肝炎(包括慢性活动性肝炎、慢性迁延性肝炎、肝硬化)、肝癌患者血清中,抗HDV抗体检出率有显著性差别,分别为0.6%、0%、1.7%、和12.1%。这些阳性血清中抗HDV抗体滴度<1:10,间隔2～6个月后对部份患者重新采血复查时,抗HDV抗体转为阴性。研究结果提示了低感染率的D型肝炎在我国的存在。

Anti-hepatitis delta virus(HDV)antibody in various HBsAg positive population has been investigated with Abbott EIA assay.Eighteen of 1004 sera were anti-HDV positive,with a percentage of 1.8.The anti-HDV positive samples of 622 asympt-omatic HBsAg carriers,58 acute hepatitis B patients, 241 chronis hepatitisB patients,and 83 primary liver cancer patients were 4(0.6%),0,4(1.7%),and 10(12.1%)respectively.Detection rate of anti- HDV was not related to the age and sex of the HBsAg positive population. The titers of these anti-HDV antibody in the sera were less than 1:10.The sera reexamination 2 after to 6 months were turned into negative anti-HDV results.The studysuggests that the incidence of hepatitis delta infection is very low in China.