含茂基稀土金属有机络合物催化剂在有机合成中的应用

Applications of Organo-Rare Earth Metallocene Catalysts in Organic Synthesis

综述了含茂基稀土金属有机络合物催化下的不饱和烃 (或其取代衍生物 )转化反应及其在有机合成中的应用。重点阐述了含茂基稀土金属有机络合物催化的烯烃氢化、氢化环化 ;烯烃和炔烃的氢化硅化 ;1,5 或 1,6 二烯或烯炔的氢化硅化 /环化 ;氨基取代烯烃、炔烃、丙二烯等的氢化胺化 /环化等反应在有机合成中的主要用途 ,这些反应在形成碳 杂原子键、碳 碳键、碳环和杂环等方面具有广泛的应用前景。讨论了这些反应的催化循环机制、区域选择性、对映选择性。

The applications of organo rare earth metallocenes in olefin transformation and in organic synthesis were reviewed. Hydrogenation and hydrogenation/cyclization of alkenes, hydrosilation of alkenes and alkynes, hydrosilation/cyclization of 1,5 and 1,6 dienes, hydroamination/cyclization of amino alkenes, alkynes and allenes catalyzed by organo rare earth metallocenes and their major applications in organic synthesis were discussed. These reactions show potential applications in C-C bond, carbon heteroatom bond, carbon rings and carbon heteroatom rings formation. The catalytic cycles of the reactions and the impact factors on regioselectivity, diastereoselectivity, enantioselectivity were also discussed.