尿NAG及尿γ-GT活性测定在小儿肾脏疾病诊治中的应用

Detection of Urinary NAG and γ-GT Activities in Children Patients with Renal Diseases

39例肾脏病患儿及195例正常儿童尿NAG与尿γ-GT活性测定结果表明:20例急性肾炎中有9例尿 NAG 升高,8例γ-GT 升高。9例肾病综合征患儿,不论初发或复发,全部尿 NAG 明显增高,8例γ-GT 增高。这两种肾脏病尿 NAG相比差异有显著性。作者认为:尿 NAG 及尿γ—GT 能较灵敏地反映原发性和继发性肾脏疾患及其损害程度。动态观察对于估计病情、评价疗效及预后有一定价值。且以尿 NAG 更敏感。

The urinary activities of NAG and γ-GT,which were determined separatelY with colorimetic analytic method and through α-aminobezene sulfonie acid development process,were reported in 195 normal children,and 39 cases with renal diseases.In 20 cases of the acute nephritis group the NAG and γ-GT increased in 9 and 8 cases respectively.9 cases of the nephrotic syndrome group,both incipient and relaped,had the increased urinarg NAG,and 8 cases had increased γ-GT.The difference of NAG between the 2 gruops was significant (p<0.05).The activities of these 2 enzymes were also reported in the cases of other renal diseases,such as purpur's nephritis,simple hematuria,renltu- bereulosis and leukemia.The 2 enzymes could be used as the sensitive indica- tions in both diagnosing primary and secondary renal diseases and reflexing the extent of these renal diseases.It is valuable for dynamic observations of NAG and γ-GT to estimate the sererity,curative effect and prognosis of renal diseases.Compared with γ-GT NAG is more sensitive.