活性氧与心肌缺血/再灌注损伤诱发的细胞凋亡
被引量:4
摘要
细胞凋亡是心肌缺血/再灌注损伤的病理特征之一,而且是损伤早期的主要死亡方式,对心肌缺血/再灌注损伤 及其转归具重要意义。活性氧学说是心肌缺血/再灌注性细胞凋亡的机制之一,本文综述了其信号转导途径及Bcl-2相关蛋白 家族,热休克蛋白对该途径的调控。
出处
《国外医学(麻醉学与复苏分册)》
CAS
2002年第2期119-122,共4页
Foreign Medical Sciences(Anesthesilolgy and Resuscitation)
参考文献1
-
1Sajal Chakraborti,Tapati Chakraborti,John R. Michael,Sandip K. Batabyal,Salil K. Ghosh. Targets of oxidative stress in cardiovascular system[J] 1998,Molecular and Cellular Biochemistry(1-2):1~10
同被引文献41
-
1贾新未,魏盟.氧化应激与血管内皮功能异常[J].国际心血管病杂志,2006,33(2):104-107. 被引量:5
-
2周军,田鸣,周兆年.异丙酚抑制大鼠心室肌细胞短暂外向钾电流[J].生理学报,1997,49(1):99-101. 被引量:9
-
3Lee MJ,Kwak YK,You KR, et al. Involvement of GADD153 and cardiac ankyrin repeat protein in cardiac ischemia-reperfusion injury. Exp Mol Med, 2009,41 : 243-252.
-
4Shirito K,Otani H, Yamamoto F, et al. MK2-/- gene knockout mouse hearts carry anti-apoptotic signal and are resistant to ischemia-reperfusion injury. J Mol cell Cardiol, 2005, 38: 93-97.
-
5Shi H. Hypoxia inducible factor 1 as a therapeutic target in ischemic stroke. Curr Med Chem, 2009,16 : 4593-4600.
-
6Yoshida H, Metoki N, Ishikawa A. Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation. Neurosci Res, 2010, 66: 284- 289.
-
7Yamamura M, Mitsuno M, Tanaka H, et al. Edaravone suppresses enclothelial cell injury in vein grafts of a rat model. Int J Angiol, 2008,17 : 221-222.
-
8Rajesh KG,Sasaguri S,Suzuki R,et al. Antioxidant MCI-186 inhibits mitoehondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol, 2003,285 : H2171-H2178.
-
9Zhang G, Matsumoto S, Hyon SH, et al. Polyphenol, an extract of green tea,increases culture recovery rates of isolated islets from nonhuman primate pancreata and marginal grade human pancreata. Cell Transplant, 2004,13 : 145-152.
-
10De Falco M,Laforgia V,Fedele V, et al. Vasoactive intestinal peptide stimulation modulates the expression of Bcl-2 family members in the adrenal gland of the lizard Podarcis sicula. Histochem J, 2001,33 : 639-645.
引证文献4
-
1田蔼萍,马平.异丙酚对缺血再灌注损伤的影响[J].实用骨科杂志,2005,11(4):335-337.
-
2郭家龙,张凯伦,蒋雄刚,夏家红,孙宗全.丙酮酸乙酯对大鼠心肌缺血再灌注细胞凋亡及Bcl-2、Bax蛋白表达的影响[J].华中科技大学学报(医学版),2007,36(2):262-264. 被引量:1
-
3滕宗艳,张海金,丛莹莹,高强,张一娜.依达拉奉对大鼠心肌再灌注损伤的保护作用及机制[J].中华老年心脑血管病杂志,2010,12(8):729-732. 被引量:1
-
4张乃君.异丙酚对缺血再灌注损伤的影响[J].武警医学院学报,2003,12(2):153-155.
-
1王建华,王玉芳.缺血心肌再灌注与心律失常[J].河北医药,1991,13(4):216-217.
-
2周书春,李铁柱,赵金凤,赵金英,邵连奎.急性心肌梗塞的静脉溶栓治疗[J].黑龙江医药,1996,9(4):213-213. 被引量:1
-
3廖若平,宋明才.再灌注性心律失常的种类及其意义[J].临床心电学杂志,1999,8(4):233-234. 被引量:1
-
4安梅,李主一.白细胞与再灌注性肺损伤[J].解放军医学情报,1992,6(2):78-81.
-
5安梅,李主一,翁龙江.再灌注性肺损伤[J].解放军医学杂志,1993,18(3):233-235. 被引量:3
-
6杨新春.急性冠脉综合征与电风暴[J].临床心电学杂志,2010,19(1):5-7. 被引量:22
-
7马雨亭,荆凤云,姬云涛,卢晓玲.溶栓疗法对急性心肌梗塞疗效观察[J].黑龙江医学,1997,0(2):11-11.
-
8赵振东,杨浩.再灌注性心律失常[J].中国急救医学,1991,11(4):29-31. 被引量:3
-
9张恩情,孙美.再灌注性心律失常[J].医学综述,1997,3(7):305-308. 被引量:6
-
10李春生.再灌注性心律失常[J].吉林医学,1990,11(1):18-19. 被引量:1