几丁聚糖在组织工程中的应用

Chitosan scaffolds for tissue engineering

支架材料作为组织工程的生物学植入替代物,对细胞移植与引导新组织生长有重要的作用。几丁聚糖可制成无毒性、无刺激性、生物相容性和生物可降解性良好的生物医用材料,在人工皮肤、骨修复材料、手术缝线等方面已广泛应用。本文分析了纯几丁聚糖支架结构和它与其他天然或合成材料复合后的支架结构的物理、化学性质及其独特的生物学功能,同时还进一步介绍了其应用的范例并探讨了发展前景。

Tissue engineering has show great promise for creating biological alternatives for implants, in which a scaffold plays a key role in seeding the cells and serves as a template for tissue regeneration. Chitosan,made of glucosamine and N-acetylgucosamine units linked by one to four glycosidic bonds,has been proven to be biologically renewable,biodegradable,biocompatible,nonantigenic,nontoxic, and biofunctional. Chitosan and some of its complexes have been studied for use in tissue engineering as a scaffolding material. These scaffoldings should meet the demand of physical, chemical and biological characterizations in demic and biologic environment. Chitosan scaffolds will get further uses in more and more fields of tissue engineering.