应激与海马

Stress and hippocampus

综述了近年来应激对海马形态和功能影响及海马对应激(HPA轴)调节的研究进展。研究表明,由于海马参与应激的感知、整合与评价,参与HPA轴应激反应,应激影响其结构与功能;而海马又可通过负反馈调节,抑制HPA轴的过度应激反应。但长期慢性应激则可削弱这种抑制作用,加重海马结构与功能的损害。

This review summarizes the present advance of effects of stress on hippocampal structure and function and the role of hippocampus in feedback regulation of thalamic-pituitary-adrenocortical (HPA)axis during stress. It shows that stress can affect hippocampal structure and function, on the other hand,the hippocampus can also suppress the stress reaction through the feedback regulation of HPA axis,but chronic stress can attenuate this regulation, then significantly impair its structure and function.