非癌性乳腺肿块的雌激素受体表达及其临床意义

Estrogen receptor expression of noncancerous breast mass and its clinical significance

目的 为了探讨女性常见良性乳腺增生病和纤维腺瘤与雌激素受体 (ER)的相关性。方法 对本院 5 3例非癌性乳腺肿块均经切取或切除活检病理诊断证实 ,(含乳腺增生病 2 4例 ,纤维腺瘤 14例 ,乳头状瘤 7例 ,乳腺腺病 8例 ) ,采用荧光组织化学法进行ER检测。结果 在 5 3例非癌性乳腺肿块组织中总的ER阳性率为 41.5 %。其中乳腺增生病、乳腺纤维腺瘤、乳管内乳头状瘤和乳腺腺病的ER表达分别为 41.7% ,16 .7% ,5 7.1%和 75 .0 %。 <5 0岁的ER阳性率为 48.7% ;而≥ 5 0岁者为 2 1.4%。表明绝经期前的ER表达水平高于绝经期后者。结论 本组中乳腺增生病的ER表达高于纤维腺瘤 ,认为非癌性乳腺肿块病人中约 1/3强属于激素依赖性 ,特别绝经期前的病人ER表达高于绝经期后者。

Objective To investigate the association of mammary fibrocystic disease and fibroadenoma with estrogen receptor(ER).Methods The noncancerous breast mass of 53 cases was confirmed by histological findings,including fibrocystic disease 24,fibroadenoma 14,papilloma 7 and adenosis 8 cases. The noncancerous tissues were assayed by using fluorescent histochemical method for contents of ER.Results The overall ER positive rate was 41.5% in noncancerous tissues of 53 cases,including ER expression of fibocystic disease,fibroadenoma,papilloma and adenosis i.e. 41.7%,16.7%,57.1% and 75.0% respectively.Although the ER positive rate was 48.7% in less than fifty years old woman,yet ER positive rate was 21.4% in ≥50 years old women,indicating that the ER level of premenopausal patients was higher than that of postmenopause(P>0.05).Conclusion The ER level of fibrocystic disease is higher than that of fibroadenoma in this series (P>0.05).We considered that approximately more than 1/3 belongs to hormone dependent patients in noncancerous breast mass and that,especially the ER expression of the premenopausal patients is higher than that of postmenopause.